Min Jee Jang

Research Interests

• Developing genetic, molecular, and computional tools for neuroscience
• Deciphering genetic and regulatory codes underlying brain dynamics
• Synthetic genetic circuit design for programmable, precision, and personalized gene delivery
• High-throughput viral and non-viral vector engineering for minimally invasive, targeted gene delivery to the mammalian nervous systems

Primary Research Area

• Neural Engineering

Research Areas

• Cell and molecular engineering
• Molecular imaging
• Quantitative biology
• Viral and genetic circuitry

Selected Articles in Journals

• Chuapoco MR, Flytzanis N, Goeden N, Octeau JC, Roxas KM, Chan KY, Scherrer J, Winchester J, Blackburn RJ, Campos LJ, Arokiaraj CM, Miles TF, Jang MJ, Vendemiatti J, Deverman BE, Pickel J, Fox AS, Gradinaru V. (2023) "Intravenous gene transfer throughout the brain of infant Old World primates using AAV", Nature Nanotechnology, 18, 1241-1251
• Jang MJ, Coughlin GM, Jackson CR, Chen X, Chuapoco MR, Vendemiatti JL, Wang ZA, Gradinaru V. (2023) "Spatial transcriptomics for profiling the tropism of viral vectors in tissues", Nature Biotechnology, 41, 1272-1286
• Kahan A, Greenbaum A, Jang MJ, Robinson JE, Cho JR, Chen X, Kassraian P, Wagenaar DA, Gradinaru V. (2021) "Light-guided sectioning for precise localization and 3D visualization of in situ optical implants", Cell Reports, 36(13), 109744
• Kumar SR, Miles TF, Chen X, Brown D, Dobreva T, Huang Q, Ding X, Luo Y, Einarsson PH, Greenbaum A, Jang MJ, Deverman BE, Gradinaru V. (2020) "Multiplexed Cre-dependent selection yields systemic AAVs for targeting distinct brain cell types", Nature Methods, 17, pp. 541-550
• Challis RC, Kumar SR, Chan KY, Challis C, Beadle K, Jang MJ, Kim HM, Rajendran PS, Tompkins JD, Shivkumar K, Deverman BE, Gradinaru V. (2019) "Systemic AAV vectors for widespread and targeted gene delivery in rodents", Nature Protocols, 14, pp. 379-414
• Chan KY, Jang MJ, Yoo BB, Greenbaum A, Ravi N, Wu W-L, Sanchez-Guardao L, Lois C, Mazmanian SK, Deverman BE, Gradinaru V. (2017) "Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systems", Nature Neuroscience, 20, pp. 1172-1179 (Cover picture)

Articles in Conference Proceedings

• Kumar SR, Chan K, Jang MJ, Huang Q, Brown D, Dobreva T, Kim HM, Luo Y, Hurt RC, Chen X, Deverman BE, Gradinaru V. (2018) "Developing AAV vectors for more efficient and selective gene expression in specific cell types of the nervous system following systemic delivery", Molecular Therapy
• Jang MJ, Coughlin GM, Zhang Y, Koulena N, Cai L, Gradinaru V. (2020) "Method for high-throughput, in situ characterization of AAV variant pools in intact tissue using ultrasensitive sequential FISH", Molecular Therapy
• Altermatt M, Brown D, Dobreva T, Jang MJ, Coughlin GM, Pool A-H, Thomson M, Gradinaru V. (2020) "In-depth parallel profiling of tissue and cell-type tropism of AAV variants by single-cell RNA sequencing", Molecular Therapy
• Kumar SR, Miles TF, Chen X, Brown D, Dobreva T, Huang Q, Ding X, Luo Y, Einarsson P, Greenbaum A, Jang MJ, Deverman BE, Gradinaru V. (2020) "Evolution and investigation of engineered AAV capsids exhibiting enhanced transduction of the central nervous system with or without murine strain specificity", Molecular Therapy
• Jang MJ, Coughlin GM, Zhang Y, Koulena, N, Schindler S, Cai L, Gradinaru V. (2021) "Deep tropism profiling of barcoded AAV capsid and cargo pools in intact tissue using high-throughput ultrasensitive sequential FISH", Molecular Therapy

Invited Lectures

• Invited seminar, Seoul National University College of Medicine, Dec 2024
• American Society for Gene and Cell Therapy, Symposium, May 2023
• Invited seminar, Yonsei University College of Medicine, May 2023
• Invited seminar, Stanford CEGS/RAMP meeting, Apr 2023
• Invited seminar, Brown University, Mar 2023
• Invited seminar, Sungkyunkwan University, Mar 2023
• Invited seminar, Seoul National University College of Medicine, Mar 2023
• Invited seminar, Korean Advanced Institute of Science and Technology, Feb 2023
• Workshop facilitator, 4th Neuronex investigator meeting, Nov 2022
• Society for Neuroscience, Nanosymposium, Nov 2022
• Mount Sinai Neuroscience seminars, Icahn School of Medicine at Mount Sinai, Oct 2022
• Postdoctoral Rising Star Symposium, University of Utah, Sep 2022
• American Society for Stereotactic and Functional Neurosurgery Biannual Meeting, Jun 2022
• Invited seminar, Korea University College of Medicine, Apr 2022
• Invited seminar, Ulsan National Institute of Science and Technology, Apr 2022

Honors

• NARSAD Young Investigator Award (2021-2023)
• Meritorious Abstract Travel Award (2021)
• Outstanding Poster Presentation Award (2020)
• Caltech Divisional Postdoctoral Fellowship (2018-2020)