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Amy E Baek

Amy E Baek
Amy E Baek
Research Assistant Professor
2244 Everitt Laboratory

Education

  • Ph.D., Molecular and Integrative Physiology, University of Michigan, Rackham Graduate School, Ann Arbor, MI, December 2014
  • Bachelor of Arts, Biological Basis of Behavior/ Minor: Anthropology, University of Pennsylvania, School of Arts and Sciences, Philadelphia, PA, May 2006

Academic Positions

  • Research Assistant Professor, Department of Bioengineering, Grainger College of Engineering, University of Illinois Urbana-Champaign, March 2019 - present
  • Post-Doctoral Fellow, Laboratory of Dr. Erik R. Nelson, Department of Molecular and Integrative Physiology, University of Illinois Urbana-Champaign, May 2015-November 2018
  • Post-Doctoral Associate, Laboratory of Dr. David J. Pinsky, Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, December 2014-April 2015
  • Graduate Student, Ph.D. Candidate, Laboratory of Dr. David J. Pinsky, Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, January 2009- December 2014

Selected Articles in Journals

  • Ma, L., Wang, L., Nelson, A.T., Han, C., He, S., Henn, M.A., Menon, K., Chen, J. J., Baek, A.E., Vardanyan, A., Shahoei, S.H., Park, S., Shapiro, D.J., Nanjappa, S.G., Nelson, E.R. (2020) 27-Hydroxycholesterol acts on myeloid immune cells to induce T cell dysfunction, promoting breast cancer progression. Cancer Letters. Doi: 10.1016/j.canlet.2020.08.020 (online ahead of print)
  • Racioppi, L., Nelson, E.R., Huang, W., Mukherjee, D., Lawrence, S.A., Lento, W., Masci, A.M., Jiao, Y., Park, S., York, B., Liu, Y., Baek, A.E., Drewry, D.H., Zuercher, W.J., Bertani, F.R., Businaro, L., Geradts, J., Hall, A., Means, A.R., Chao, N., Chang, C., McDonnell, D.P. (2019) CaMKK2 in myeloid cells is a key regulator of the immune-suppressive microenvironment in breast cancer. Nature Communications. 10(1):2450
  • He, S., Ma, L., Baek, A.E., Vardanyan, A., Vembar, V., Chen, J.J., Nelson, A.T., Burdette, J.E., Nelson, E.R. (2019) Host CYP27A1 expression is essential for ovarian cancer progression. Endocrine Related Cancer. 26 (7): 659-675
  • Sutton, N.R., Hayasaki, T., Hyman, M.C., Anyanwu, A.C., Petrovic-Djergovic, D., Badri, L., Baek, A.E., Liao, H., Walker, N.W., Kanthi, Y., Pinsky, D.J. (2017) Ectonucleotidase CD39-driven control of postinfarction myocardial repair and rupture. JCI Insight. 2(1):e89504
  • Baek, A.E., Sutton, N.R., Petrovic-Djergovic, D., Liao, H., Ray, J.J., Park, J., Kanthi, Y., Pinsky, D.J. (2017) Ischemic cerebroprotection conferred by myeloid lineage-restricted or global CD39 transgene expression. Circulation. 135(24):2389-2402
  • Bally-Le Gall, F., Hussal, C., Kramer, J., Cheng, K., Kumar, R., Eyster, T., Baek, A., Troullet, V., Nieger, M., Bräse, S., Lahann, J. (2017) Polylutidines: Multifunctional Surfaces through Vapor-Based Polymerization of Substituted Pyridinophanes. Chemistry. 23(54): 13342-13350
  • Baek, A.E., Yu, Y.A., He, S., Wardell, S.E., Chang, C.Y., Kwon, S., Pillai, R.V., McDowell, H.B., Thompson, J.W., Dubois, L.G., Sullivan, P.M., Kemper, J.K., Gunn, M.D., McDonnell, D.P., Nelson, E.R. (2017) The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells. Nature Communications. 8(1):864
  • Kanthi, Y., Hyman, M.C., Liao, H., Baek, A.E., Visovatti, S.H., Sutton, N.R., Goonewardena, S.N., Neral, M.K., Jo, H., Pinsky, D.J. (2015) Flow dependent expression of ecto-apyrase CD39 and suppression of atherosclerosis. J Clin Invest. 125(8):3027-3036
  • Baek, A.E., Nelson E.R. (2016) The contribution of cholesterol and its metabolites to the pathophysiology of breast cancer. Hormones and Cancer. Aug;7(4):219-28
  • Sutton, N., Baek, A., and Pinsky, D.J. Endothelial cells and inflammation. In Mackay I, Rose NR (Eds.), Encyclopedia of Medical Immunology. New York, New York, USA: Springer press; (2014):367-381
  • Baek, A.E., Kanthi, Y., Sutton, N.R., Liao, H., and Pinsky, D.J. (2013) Regulation of ecto-apyrase CD39 (ENTPD1) expression by phosphodiesterase III (PDE3). FASEB J. 27, 4419-4428
  • Bentley, J. K., Popova, A. P., Bozyk, P. D., Linn, M. J., Baek, A. E., Lei, J., Goldsmith, A. M., and Hershenson, M. B. (2010) Ovalbumin sensitization and challenge increases the number of lung cells possessing a mesenchymal stromal cell phenotype. Respir Res. 11(1):127
  • Liao, H., Hyman, M. C., Baek, A. E., Fukase, K., and Pinsky, D. J. (2010) cAMP/CREB-mediated transcriptional regulation of ectonucleoside triphosphate diphosphohydrolase 1 (CD39) expression. J Biol Chem. 285 (19): 14791-14805
  • Moldobaeva, A., Baek, A., Eldridge, L., and Wagner, E. M. (2010) Differential activity of pro-angiogenic CXC chemokines. Microvasc Res. 80, 18-22
  • Moldobaeva, A., Baek, A., and Wagner, E. M. (2008) MIP-2 causes differential activation of RhoA in mouse aortic versus pulmonary artery endothelial cells. Microvasc Res. 75, 53-58

Invited Lectures

  • Extracellular Vesicles (EVs) and their role in breast cancer progression.
  • Modulation of Thromboprotective enzyme ENTPD1 (CD39) by phosphodiesterase 3 inhibition.
  • The Microenvironment of CD39: Caveolae and the effects of statins.

Honors

  • Post-doctoral Fellowship - Susan G. Komen (August 2016-August 2019)
  • Finalist - Horace A. Davenport Award for Research Excellence (April 2013)
  • Pre-doctoral Fellowship-Midwest affiliate, American Heart Association Systems and Integrative Biology training grant (January 2012 - December 2013)
  • Systems and Integrative Biology training grant (August 2009- December 2011)
  • Rackham Merit Fellowship (August 2008-August 2010)
  • Systems and Integrative Biology training grant (August 2008 - July 2009)
  • Valedictorian- Herbert Hoover High School, Glendale, CA (June 2002)