Department of Bioengineering Annual Report 2024-2025

Our First in the Nation Neural Engineering Program

Illinois continues to lead the way in shaping the future of neurotechnology. As the first undergraduate program in Neural Engineering in the nation, our degree offers a one-of-a-kind opportunity for students to explore how the brain interfaces with machines, therapies, and computation. Now in its third year, the program is drawing students interested in combining neuroscience, bioinstrumentation, and systems engineering to push the boundaries of what’s possible in brain-computer interfaces, neural prosthetics, and cognitive health technologies.

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Our Innovative Blended Computer Science + Bioengineering Program

Our Computer Science + Bioengineering degree offers students a foundation at the intersection of computational thinking and human health. As we welcome our second cohort this year, students will deepen their understanding of both disciplines.  Students will apply algorithms and perform data analysis and modeling to solve complex challenges in areas like biomedical imaging, diagnostics, and bioinformatics. This integrated approach prepares them to contribute meaningfully to research, medicine, and health technology. We look forward to another exciting year ahead as these students bring fresh ideas and energy to work that will shape the future of healthcare and biomedical discovery.

   

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FIGHTING CANCER
with engineering

The University of Illinois Grainger Engineering is pioneering innovative approaches to combat cancer through advanced engineering principles and interdisciplinary collaboration. In 2024, Grainger researchers received two prestigious ARPA-H grants totaling $54 million to develop transformative solutions for cancer treatment. Professor Stephen Boppart’s Margin Diagnostics project aims to enhance cancer surgery outcomes using AI-powered imaging, while Professor Bill King’s MASCOT initiative focuses on creating uniform 3D tumor models for individualized treatment research. These efforts, bolstered by partnerships across campus and with leading clinical institutions, underscore Illinois’ commitment to accelerating cancer research and delivering impactful healthcare solutions.

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Drug-Delivering Aptamers Target Leukemia Stem Cells for One-Two Knockout Punch

Drug-carrying DNA aptamers can deliver a one-two punch to leukemia by precisely targeting the elusive cancer stem cells that seed cancer relapses, researchers at the University of Illinois Urbana-Champaign report. “This work demonstrates a way to get to the root of leukemia,” says bioengineering professor Xing Wang. “Targeted cancer treatments often have problems with toxicity or efficacy. Our aptamers seek out these stem cells specifically and kill them effectively.” 

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Hua Wang Uses Materials Engineering to Create Cancer Vaccines

In developing robust cancer vaccines and immunotherapy, biomaterials that can facilitate “reprogramming” of the immune system could be a game-changer. That is where materials science & engineering and bioengineering professor Hua Wang comes in. He develops material complexes that, when injected, trap immune cells and reprogram them to target cancerous cells. He is leading a $946,000 grant from the American Cancer Society to develop mRNA therapeutics based on biomaterial scaffolds. 

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Michael Oelze is Bringing Ultrasound to Cancer Treatment

Technologies like MRI and X-ray CT have revolutionized medicine by allowing clinicians to noninvasively observe features within the body with high precision. However, they are expensive, and it can take months for changes in a tumor to appear in scans. Some researchers are exploring an alternative: ultrasound. Professor Michael Oelze is leading two initiatives, both funded by the National Institutes of Health, to study uses of ultrasound in breast cancer treatment.  

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PFAS found in nearly all fish tested from four northern Illinois rivers

Scientists tested nine fish species from four northern Illinois rivers for contamination with per- or polyfluoroalkyl substances, synthetic chemicals found in numerous industrial and commercial products and known to be harmful to human health. They found fish contaminated with PFAS in every one of their 15 test sites. Elevated levels of PFOS, one type of PFAS compound, were found in nearly all fish tested. The qualities that make PFAS desirable for industrial uses also make these chemicals particularly problematic in the environment and hazardous to human and animal health, said Joseph Irudayaraj, a professor of bioengineering at Illinois who led the new study.  

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Bioengineering Laboratory Innovates Cell Labeling

Researchers in Andrew Smith’s lab, including postdoc Yujun Feng, have developed “nanocoding,” a new way to tag cells using lipid nanoparticles that deliver DNA barcodes directly into cells, overcoming issues like uneven labeling or toxicity seen with traditional methods. By treating cells with simple chemical linkers, every cell gets a stable, non-toxic label that won’t fall off or swap, enabling mixed-sample experiments under identical conditions. This accessible technique, requiring only commercially available reagents and minimal training, could accelerate research into diseases such as cancer, obesity, and aging by making single-cell studies faster, cheaper, and more reliable.

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Bioengineering Laboratory Makes Strides in Gut Health

Researchers in professor Shannon Sirk’s bioengineering lab are developing a system to harness gut bacteria for therapeutic protein delivery, with promising implications for treating inflammatory bowel disease and other gastrointestinal conditions. Their recent Nature Communications paper details how engineered Bacteroides species can secrete beneficial proteins directly into the gut or via protective outer membrane vesicles. This innovation, combined with precise control over protein production, could enable real-time, patient-specific treatments that respond to disease flare-ups. This research represents a crucial step in microbiome-based medicine.

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Bioengineers Create Revolutionary New Nanocrystals

Andrew Smith's lab has developed a novel one-step method to synthesize water-soluble nanocrystals by using alkoxy ligands, overcoming the instability and environmental waste issues of traditional oil-based synthesis. This breakthrough technique produces nanocrystals that are remarkably stable and uniformly dispersed in water, making them more suitable for biomedical applications. The method significantly reduces hazardous byproducts and is easier to scale, paving the way for widespread use in fields such as drug delivery and medical testing. Smith’s innovation is poised to become a foundational technology for future advancements in both medicine and materials science.

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Jump ARCHES Aids Funding for Detection of E. Coli Bypassing Blood Culture

The Grainger College of Engineering's Jump ARCHES Research Program awarded funding to a project led by Rashid Bashir, Enrique Valera, and John Farrell to develop a diagnostic tool for detecting E. coli without relying on blood cultures. Current blood culture methods delay results, increasing mortality risk for sepsis patients with each hour of delay.  Researchers aim to refine this method, test it on clinical samples, and assess its viability in real-world healthcare settings, particularly benefiting under-resourced regions.

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Revolutionizing Cardiac Amyloidosis Diagnosis with AI and Infrared Spectroscopy

Illinois bioengineering professor Rohit Bhargava, research scientist Sudipta Mukherjee, and a multidisciplinary team have developed a groundbreaking diagnostic method for cardiac amyloidosis using infrared spectroscopic imaging and AI. Current diagnostic techniques require invasive biopsies, specialized facilities, and extensive wait times. The new method uses a specialized infrared microscope to detect molecular “fingerprints” of proteins, analyzed by an AI neural network trained to identify those causing amyloidosis. 

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Gene Editing Tool Reduces Alzheimer's Plaque Precursor in Mice

Researchers at the University of Illinois Urbana-Champaign have developed SPLICER, a new gene-editing tool that efficiently skips over disease-causing gene sequences. In a significant breakthrough, the team demonstrated its ability to reduce amyloid-beta plaque precursors in a mouse model of Alzheimer’s disease, a milestone in genetic research. SPLICER improves upon the CRISPR-Cas9 platform by expanding its target range and enhancing precision, addressing limitations in current exon-skipping methods.

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Bioengineering Professor Shuming Nie Reaches 100,000 Academic Citations

Bioengineering professor Shuming Nie has reached an extraordinary milestone—his work has now been cited over 100,000 times, making him one of the most influential researchers in his field. Two of his landmark papers—from 1997 on detecting single molecules with surface-enhanced Raman scattering and from 1998 on fluorescent quantum dots—have each been cited more than 10,000 times, a feat achieved by fewer than 0.01% of scientific publications. Nie credits this success to a mix of “serendipity” and rigorous preparation.

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Bioengineering Department Head Mark Anastasio Receives IEEE EMBS Morlock Award

Bioengineering Department Head Mark Anastasio has been awarded the William J. Morlock Award from the Institute of Electrical and Electronics Engineers (IEEE) Engineering in Medicine and Biology Society (EMBS), one of the most prestigious honors presented by that group. This award recognizes the depth of Anastasio’s contributions to the medical imaging community, particularly at the intersection of artificial intelligence and imaging. He has consistently been on the cutting edge of novel imaging modalities and developing innovative ways to analyze data, improving accuracy, imaging speed, and accessibility. “I am honored and humbled to receive this award,” said Anastasio. “It is always gratifying to be recognized by colleagues that I respect highly.”

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A bioengineering graduate smiles at the camera in a cap and gown.

 Brendan O'Rourke, B.S. 2025

"The Department of Bioengineering at Illinois facilitated my growth both as an engineer and as a person. I learned how to turn my ideas into something tangible, and how to share my passions with those around me. The department's holistic approach to engineering provided me with hands-on skills that I couldn't find anywhere else. Currently, I'm pursuing my master's thesis at Northwestern University through the Shirley Ryan Ability Lab. Our research aims to restore the feeling of touch & proprioception to amputees through revolutionary neural prosthetics. Much of our work involves interacting directly with patients. The Department of Bioengineering's collaborations with the Carle Illinois College of Medicine provided me with the skills necessary to strive for excellence in research & clinical settings."

 

Hannah Kimmel smiles at the camera.

Hannah Kimmel, Ph.D. 2025

"I chose the Bioengineering PhD program at Illinois for its collaborative approach to research, emphasis on interdisciplinary teams, great resources, and passionate faculty. During my PhD studies, I was fortunate to have a strong support system not only from my advisor and lab, but also my fellow graduate students and other faculty members. I was able to take advantage of many opportunities to expand my horizons beyond my research in the lab, including the Mavis Future Faculty Fellowship and Tissue Microenvironment Training Program. The resources available to graduate students were truly top notch and the staff at IGB and Beckman were incredibly helpful and patient with me." Hannah Kimmel is an assistant professor in biology and biomedical engineering at the Rose-Hulman Institute of Technology. 

Applegate smiles by a microscope.

Catherine Applegate, Ph.D., Postdoc, 2025

"After experiencing my own cancer diagnoses, I joined bioengineering at Illinois for my postdoctoral studies to figure out where I could maximize my personal impact on cancer treatment. I most appreciated the interdisciplinary and collaborative environment that enabled me to work with and learn from various cross-functional projects and highly supportive mentors. I am now in my dream role as a medical science liaison at a biotech company that develops cancer therapies, where I am able to leverage my knowledge and experience gained from my postdoc with BioE to understand and communicate complex drug mechanisms with the ultimate goal of getting cancer patients the right drug at the right time." Learn more about Catherine's unique experience here.

Carle Illinois College of Medicine

Carle Illinois College of Medicine — the world’s first engineering-based college of medicine — was born out of The Grainger College of Engineering. It embodies a visionary collaboration with the Department of Bioengineering, fundamentally re-engineering medicine by integrating engineering, AI, design thinking and clinical practice into a problem-solving curriculum. Carle Illinois earned full accreditation from the Liaison Committee on Medical Education (LCME) in March 2025, affirming the excellence of its pioneering model and securing its future as a transformative force in health education. Carle Illinois has also emerged as a global leader in innovation and medical education through the launch of the Global Consortium of Innovation and Engineering in Medicine. In just one year, more than 36 universities joined the consortium, and in April 2025, CI MED hosted its inaugural Global Summit, drawing over 500 participants worldwide. The event highlighted bold ideas and student-led innovations, with CI MED teams earning top honors on the global stage.


<!--StartFragment--><span data-olk-copy-source="MessageBody">Carle Illinois College of Medicine students practice their skills at the Jump Simulation Center </span>
Carle Illinois College of Medicine students in the state-of-the-art Jump Simulation Center 

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Cancer Center at Illinois

The Cancer Center at Illinois (CCIL) began in 2011 when bioengineering professor Rohit Bhargava and a community of researchers envisioned becoming a cancer research powerhouse. From there, the CCIL has grown into a nationally recognized basic sciences research institution that pushes forward the frontiers of cancer research. Recently, the CCIL submitted a Cancer Center Support Grant to the National Cancer Institute (NCI) to become an NCI-Designated Cancer Center. Of the 73 designated cancer centers nationwide, only seven are basic science laboratories, and the CCIL is seeking to become the first center since 1987 to earn this accreditation. Bhargava, now the Phillip and Ann Sharp Director of the CCIL, said, “The department inspired us to form the CCIL. We are now poised to lead a national movement at the convergence of engineering and oncology, and the CCIL has applied to become the first NCI-Designated Basic Laboratory Cancer Center focused on engineering. We anticipate that the approach pioneered by Illinois Bioengineering and the CCIL will lead to a pipeline of innovations that seek to save and improve the lives of those affected by cancer.”

Bioengineering professor and CCIL Director Rohit Bhargava 
Bioengineering professor and CCIL Director Rohit Bhargava 

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First-Generation Scholars Research Program provides research experience and more

 

First-generation student Andy Granados overcame his freshman-year jitters by joining Illinois' First-Generation Scholars Research Program, where he now works with bioengineering professor Holly Golecki to build soft robotic organ models for STEM outreach. Granados is designing a squishy heart model powered by McKibben muscle actuators that pumps fluids at realistic rates, helping grade-schoolers explore bioengineering concepts. Funded by the Office of Undergraduate Research, the Jeffries Center, and the Provost’s Office, FGSRP gives federal work-study eligible first-gen students mentored research experiences and a supportive community.

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Ashley Oliver named 2025 Lincoln Academy Student Laureate

Lincoln Academy Student Laureates from colleges and universities across the state are honored by the governor for their overall excellence in civic engagement and curricular and extracurricular activities. Each selected Student Laureate will receive the Lincoln Academy Student Laureate Medallion and a certificate of achievement. "The fact that the school felt I was an appropriate person to nominate, let alone receive the award, was very heartwarming to me," said Ashley. "It made me feel that my school is watching and enjoys me being there as much as I enjoy being at the school."

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Laboratory and Classroom Partnership Connects High School Students with Brain Research

Bioengineering professor Yuan Yang at the University of Illinois Urbana-Champaign partnered with high school teacher Cyndi Smyser to transform stroke research into an engaging high school curriculum. Supported by Yang’s NSF CAREER award, this collaboration brought MRI data into Smyser's anatomy and physiology class at University Laboratory High School. Students explored 3D brain images, identifying stroke-related lesions and gaining insights into brain structure beyond textbook diagrams. 

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Six bioengineering students selected as 2024 Mayo Clinic Summer Undergraduate Research Fellows

Six bioengineering students were selected to participate in the 2024 Mayo Clinic Summer Undergraduate Research Fellows (SURF) program. Participants will join approximately 180 undergraduates from across the nation this summer during a 10-week program during which they'll work in the laboratories of Mayo Clinic faculty on small research projects.

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Master of Engineering in Bioengineering

Designed for engineers and scientists seeking careers in the health care industry, this one-year professional master’s program prepares students to become industry leaders. The curriculum blends rigorous engineering coursework with foundational business skills. Graduates are driving innovation across health-related industries using a unique combination of bioengineering and business perspectives. With concentrations in Bioinstrumentation and General Bioengineering, the program is offered both in-person and online.

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Master of Science in Biomedical Image Computing

Biomedical image computing is a fast-growing, interdisciplinary field focused on the formation and analysis of biomedical images and the development of imaging systems using computational and data-driven methods. With rapid advances in AI and computing, there is increasing demand for professionals skilled in imaging, high-performance computing, and AI. The Master of Science in Biomedical Image Computing, offered in-person and online, provides focused training at this exciting intersection.

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3 Undergraduate Degree Programs

 

  • Bioengineering
  • Neural Engineering
  • CS+BioE

4 Graduate
Degree Programs

 

  • PhD in Bioengineering
  • MS in Bioengineering
  • MS in Biomedical Image Computing
  • Master of Engineering in Bioengineering