BIOE: Aaron Meyer - "High-dimensional analysis to map and manipulate immune receptor-ligand families"
(sign-up)Aaron S. Meyer, Ph.D., Assistant Professor, Department of Bioengineering, University of California, Los Angeles
|Time:||12 p.m. - 1 p.m.|
|Location:||2310 Everitt Laboratory, 1406 W Green St, Urbana, IL|
|Event Contact:||Lisa Leininger
|Sponsor:||Department of Bioengineering|
"High-dimensional analysis to map and manipulate immune receptor-ligand families"
Receptor-ligand families within the immune system commonly feature regulation through multiple ligands and receptors, expressed in distinct combinations across cell populations. This structure ensures that any drug targeting these families, including many approved therapies, has pleiotropic effects within and across cell types. Mapping this regulation, and the changes occurring with therapy, should allow us to design better therapies alone and in combinations.
In this talk, I will show this is a challenge in antibody drug design as the Fcγ receptors which enact effector cell responses to IgGs operate in combination and across cell types. Using a mechanism-based binding model with data-driven analysis allows one to predict the effect of anti-tumor antibodies better than using existing design criteria. Building upon this work and looking at the common gamma chain cytokines, another focus of immunotherapy development, I will discuss some very general strategies for mapping regulation of these receptor-ligand families.
About the Speaker:
Dr. Meyer is an assistant professor in the Department of Bioengineering at the University of California, Los Angeles. He received his B.S. in Bioengineering from the University of California, Los Angeles, and Ph.D. in Biological Engineering from the Massachusetts Institute of Technology. The Meyer lab focuses on combining experimental and computational techniques to reverse engineer cancer and innate immune signaling, with the goal of designing immune-and cancer-targeted therapies.
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