BIOE: Marjolein C. H. van der Meulen - "Role of Estrogen Signaling in Musculoskeletal Adaptation"

Speaker Marjolein C. H. van der Meulen, James M. & Marsha McCormick Chair and Swanson Professor of Biomedical Engineering, Nancy E. & Peter C. Meinig School of Biomedical Engineering, Sibley School of Mechanical & Aerospace Engineering, Cornell Un
Date: 2/13/2018
Time: 11 a.m. - 12 p.m.

2240 Digital Computer Lab, 1304 W Springfield Avenue, Urbana, IL

Event Contact: Lisa Leininger

Department of Bioengineering

Event Type: Seminar/Symposium

"Role of Estrogen Signaling in Musculoskeletal Adaptation"


Dynamic mechanical loading is an anabolic agent that inhibits loss of bone mass and strength and could counteract the skeletal changes that occur in aging postmenopausal women. However, most of our knowledge of defined mechanical loads on bone formation is based on cortical bone in healthy animals. Our group has focused on understanding bone adaptation in corticocancellous bone in vivo. Here I will discuss our work examining the role of estrogen signaling in mechanotransduction. First, we demonstrated that mechanotransduction in cancellous bone was not affected by lack of circulating estrogen. This result led us to more closely examine the role of the estrogen receptors in bone cells, which have been shown to be critical effectors of loading in vitro.  We showed that deletion of the estrogen receptor in cells of the osteoblast lineage decreased bone mass in young and adult female mice, but increased responsiveness to loading in young female mice. These effects were not present in male mice Preliminary data addressing the in vivo mechanisms whereby signaling through estrogen receptors attenuates cancellous mechanotransduction will also be discussed. 

About the Speaker:

Marjolein C. H. van der Meulen is the James M. & Marsha McCormick Chair and Swanson Professor of Biomedical Engineering in the Nancy E. & Peter C. Meinig School of Biomedical Engineering and the Sibley School of Mechanical & Aerospace Engineering at Cornell University. She is also a Senior Scientist at the Hospital for Special Surgery. Her research in orthopaedic biomechanics focuses on musculoskeletal mechanobiology and bone biomechanics. She is a member of the American Society for Bone and Mineral Research (ASBMR), the Biomedical Engineering Society (BMES), and the Orthopaedic Research Society (ORS). She is an associate editor of the Journal of Bone and Mineral Research, member of the BMES board, and serves on the World Council of Biomechanics.  

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