BIOE: John Fisher, "3D Printing for Engineering Complex Tissues"
(sign-up)Dr. John P. Fisher, Fischell Family Distinguished Professor & Department Chair, Fischell Department of Bioengineering, University of Maryland, College Park, MD
2310 Everitt Laboratory, 1406 W Green Street, Urbana
|Event Contact:||Lisa Leininger
Department of Bioengineering
"3D Printing for Engineering Complex Tissues"
The generation of complex tissues has been an increasing focus in tissue engineering and regenerative medicine. With recent advances in bioprinting technology, our laboratory has focused on the development of platforms for the treatment and understanding of clinically relevant problems ranging from congenital heart disease to preeclampsia. We utilize stereolithography-based and extrusion-based additive manufacturing to generate patient-specific vascular grafts, prevascular networks for bone tissue engineering, dermal dressings, cell-laden models of preeclampsia, and bioreactors for expansion of stem cells. Furthermore, we have developed a range of UV crosslinkable materials to provide clinically relevant 3D printed biomaterials with tunable mechanical properties. Such developments demonstrate the ability to generate biocompatible materials and fabricated diverse structures from natural and synthetic biomaterials. In addition, one of the key challenges associated with the development of large tissues is providing adequate nutrient and waste exchange. By combining printing and dynamic culture strategies, we have developed new methods for generating macrovasculature that will provide adequate nutrient exchange in large engineered tissues. Finally, the use of stem cells in regenerative medicine is limited by the challenge in obtaining sufficient cell numbers while maintaining self-renewal capacity. Our efforts in developing 3D-printed bioreactors that mimic the bone marrow niche microenvironment have enabled successful expansion of mesenchymal stem cells by recapitulating the physiological surface shear stresses experienced by the cells. This presentation will cover the diverse range of materials and processes developed in our laboratory and their application to relevant, emerging problems in tissue engineering.
About the Speaker:
Dr. John P. Fisher is the Fischell Family Distinguished Professor and Department Chair in the Fischell Department of Bioengineering at the University of Maryland. Dr. Fisher is also the Director of the newly established NIBIB / NIH Center for Engineering Complex Tissue (CECT) that aims to create a broad community focusing on 3D printing and bioprinting for regenerative medicine applications. Dr. Fisher completed a B.S. in biomedical and chemical engineering at The Johns Hopkins University (1995), M.S. in chemical engineering at the University of Cincinnati (1998), Ph.D. in bioengineering at Rice University (2003), and postdoctoral fellowship in cartilage biology and engineering at the University of California Davis (2003).
As the Director of the Tissue Engineering and Biomaterials Laboratory, Dr. Fisher’s group investigates biomaterials, stem cells, bioprinting, and bioreactors for the regeneration of lost tissues, particularly bone, cartilage, and cardiovascular tissues. Overall, the laboratory has published over 140 articles, book chapters, and proceedings (5000+ citations / 40+ h-index) as well as delivered over 285 invited and contributed presentations, while utilizing over $15M in financial support from NIH, NSF, FDA, NIST, DoD, and other institutions. Dr. Fisher has been elected Fellow of both the American Institute for Medical and Biological Engineering (2012) and the Biomedical Engineering Society (2016). Dr. Fisher is currently the Co-Editor-in-Chief of the journal Tissue Engineering, as well as the Chair (2018 - 2020) of the Americas Chapter of the Tissue Engineering and Regenerative Medicine International Society (TERMIS-AM). In 2018, Dr. Fisher will co-chair the Biomedical Engineering Society (BMES) Annual Meeting, celebrating the 50th Anniversary of the Society.
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