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BIOE: Millicent Sullivan - "Unlocking Intracellular Therapeutic Targets through Novel Nanostructured Biomaterials"

Speaker Millicent O. Sullivan, Ph.D., Centennial Associate Professor, Chemical & Biomolecular Engineering, University of Delaware
Date: 1/23/2018
Time: 11 a.m. - 12 p.m.
Location:

2240 Digital Computer Lab, 1304 W Springfield Avenue, Urbana, IL

Event Contact: Lisa Leininger
217-300-1044
leininge@illinois.edu
Sponsor:

Department of Bioengineering

Event Type: Seminar/Symposium
 

"Unlocking Intracellular Therapeutic Targets through Novel Nanostructured Biomaterials"

 

Abstract:

Our group addresses challenges in drug and gene delivery by coupling principles in molecular design, molecular self-assembly, and chemical reaction kinetics with principles of cell and extracellular matrix (ECM) biology and the cell-material interface.  In particular, soft materials (e.g. polymers and peptides) exhibit enormous chemical and mechanical tunability and have been self-assembled by our group and others into a versatile array of gene and drug-loaded nanostructures.  We are particularly interested in developing nature-inspired approaches to harness native gene delivery and regulation mechanisms, and to actively control self-assembly vs. disassembly in gene and drug-loaded structures.  This talk will highlight ways in which our laboratory has develop and use nanoscale materials to understand and probe cellular "unit ops,” with long-term applications including targeted drug delivery for prostate and breast cancer, and gene therapy for wound and tissue repair.

 

About the Speaker:

Millicent Sullivan is the Centennial Associate Professor of Chemical & Biomolecular Engineering at the University of Delaware.  Sullivan graduated from Princeton University with a B.S.E. degree in Chemical Engineering and a Certificate in Engineering Biology in 1998.  Subsequently, she attended Carnegie Mellon University as a Clare Boothe Luce Graduate Fellow, where she earned her Ph.D. degree in Chemical Engineering with Professor Todd Przybycien in 2003.  As a Ruth L. Kirchstein NIH postdoctoral fellow, Sullivan worked with Professor E. Helene Sage in the Matrix Biology/Hope Heart Program of the Benaroya Research Institute.  In 2006, Sullivan moved to the University of Delaware.  Her laboratory develops new biomaterials for drug delivery, gene delivery, and tissue engineering, with specific therapeutic targets including metastatic breast cancer, bone repair, and wound healing. 

 

Specific fundamental foci include de novo peptide design, peptide and polymer self-assembly, and subcellular processing mechanisms.  Sullivan is a faculty member in the Delaware Biomaterials COBRE, a member of the Penn Center for Targeted Therapeutics and Translational Nanomedicine (CT3N), an Affiliate Member of the Delaware Biotechnology Institute, and an Affiliate Faculty in the Department of Biomedical Engineering at UD.  She was selected as an AIMBE fellow in 2017, named as a Georgia Tech Frontiers in Bioengineering Young Investigator in 2013, selected as the Outstanding Junior Faculty in Engineering at UD in 2011, and has received various other awards including the NSF CAREER Award and a Merck Faculty Fellow Award.

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