directory

Yong-Su Jin

Yong-Su Jin
Assistant Professor
(217) 333-7981
1105 Institute for Genomic Biology
(217) 333-7981
1105 Institute for Genomic Biology

Research Topics

  • Synthetic Bioengineering

Education

  • Ph.D., University of Wisconsin, Madison
  • M.S., Seoul National University, Korea
  • B.S., Seoul National University, Korea

Academic Positions

  • Assistant Professor, Sungkyunkwan University, Korea, 03/01/2006-08/15/2008

For more information

Research Topics

  • Synthetic Bioengineering

Research Interests

  • Metabolic engineering, which draws upon the key engineering principles of integration and quantification, is a platform technology that provides solutions to various biological problems in the context of systems and synthetic biology. In particular, we are interested in developing and applying systematic and combinatorial methods for strain improvement for the production of fuels, chemicals, and nutraceuticals. Also, we would like to extend these methods for studying fundamental biology problems, such as aging and stress response. The overall goals of our research are (1) to develop useful/efficient computational and experimental tools for the dissection of complex metabolic networks in microbial cells, and (2) to create optimal strains for biotechnological processes using these developed tools.
  • Probing, characterizing, and engineering cellular state through systems and synthetic biology; Metabolic engineering for production of value added products (fuels, chemicals, and nutraceuticals)

Selected Articles in Journals

  • Jayakody, L. N., Lane, S., Kim, H., and Jin, Y. S. (2016) Mitigating health risks associated with alcoholic beverages through metabolic engineering. Current Opinion in Biotechnology 37, 173-181
  • Kim, J. S., Cho, D. H., Heo, P., Jung, S. C., Park, M., Oh, E. J., Sung, J., Kim, P. J., Lee, S. C., Lee, D. H., Lee, S., Lee, C. H., Shin, D., Jin, Y. S., and Kweon, D. H. (2016) Fumarate-mediated persistence of Escherichia coli against antibiotics. Antimicrobial Agents and Chemotherapy 60, 2232-2240
  • Li, X., Park, A., Estrela, R., Kim, S. R., Jin, Y. S., and Cate, J. H. D. (2016) Comparison of xylose fermentation by two high-performance engineered strains of Saccharomyces cerevisiae. Biotechnology Reports 9, 53-56
  • Liu, J. J., Kong, II, Zhang, G. C., Jayakody, L. N., Kim, H., Xia, P. F., Kwak, S., Sung, B. H., Sohn, J. H., Walukiewicz, H. E., Rao, C. V., and Jin, Y. S. (2016) Metabolic engineering of probiotic Saccharomyces boulardii. Applied and Environmental Microbiology 82, 2280-2287
  • Park, Y. C., Oh, E. J., Jo, J. H., Jin, Y. S., and Seo, J. H. (2016) Recent advances in biological production of sugar alcohols. Current Opinion in Biotechnology 37, 105-113
  • Seo, J. H., and Jin, Y. S. (2016) Editorial overview: Food biotechnology: Critical gap filler in the nexus of food, energy, and waste for a prosperous future. Current Opinion in Biotechnology 37, 4-7
  • Xia, P. F., Zhang, G. C., Liu, J. J., Kwak, S., Tsai, C. S., Kong, II, Sung, B. H., Sohn, J. H., Wang, S. G., and Jin, Y. S. (2016) GroE chaperonins assisted functional expression of bacterial enzymes in Saccharomyces cerevisiae. Biotechnology and Bioengineering 113, 2149-2155
  • Xu, H., Kim, S., Sorek, H., Lee, Y., Jeong, D., Kim, J., Oh, E. J., Yun, E. J., Wemmer, D. E., Kim, K. H., Kim, S. R., and Jin, Y. S. (2016) PHO13 deletion-induced transcriptional activation prevents sedoheptulose accumulation during xylose metabolism in engineered Saccharomyces cerevisiae. Metabolic Engineering 34, 88-96
  • Oh, E. J., Skerker, J. M., Kim, S. R., Wei, N., Turner, T. L., Maurer, M. J., Arkin, A. P., and Jin, Y. S. (2016) Gene amplification on demand accelerates cellobiose utilization in engineered Saccharomyces cerevisiae. Applied and Environmental Microbiology 82, 3631-3639
  • Wang, Y., Zhang, Z. T., Seo, S. O., Lynn, P., Lu, T., Jin, Y. S., and Blaschek, H. P. (2016) Bacterial genome editing with CRISPR-Cas9: deletion, integration, single nucleotide modification, and desirable "clean" mutant selection in Clostridium beijerinckii as an example. ACS Synthetic Biology 15, 721-732
  • Quarterman, J., Skerker, J. M., Feng, X., Liu, I. Y., Zhao, H., Arkin, A. P., and Jin, Y. S. (2016) Rapid and efficient galactose fermentation by engineered Saccharomyces cerevisiae. Journal of Biotechnology 229, 13-21
  • Bode, L., Contractor, N., Barile, D., Pohl, P., Prudden, A., Boons, G.-J., Jin, Y. S., and Jennewein, S. (2016) Human Milk Oligosaccharides: Challenges and opportunities Nutrition Reviews, in press
  • Wang, Y., Zhang, Z. T., Seo, S. O., Lynn, P., Lu, T., Jin, Y. S., and Blaschek, H. (2016) Gene transcription repression in Clostridium beijerinckii using CRISPR-dCas9. Biotechnology and Bioengineering, 113, 2739-2743
  • Zhang, G. C., Kong, II, Wei, N., Peng, D., Turner, T. L., Sung, B. H., Sohn, J. H., and Jin, Y. S. (2016) Optimization of an acetate reduction pathway for producing cellulosic ethanol by engineered yeast. Biotechnology and Bioengineering, 113, 2587-2596
  • Liu, J. J., Zhang, G. C., Oh, E. J., Pathanibul, P., Turner, T. L., and Jin, Y. S. (2016) Lactose fermentation by engineered Saccharomyces cerevisiae capable of fermenting cellobiose. Journal of Biotechnology 234, 99-104
  • Kim, J. W., Kim, J., Seo, S. O., Kim, K. H., Jin, Y. S., and Seo, J. H. (2016) Enhanced production of 2,3-butanediol by engineered Saccharomyces cerevisiae through fine-tuning of pyruvate decarboxylase and NADH oxidase activities. Biotechnology for Biofuels, 9, 265
  • Choi, E. J., Kim, J. W., Kim, S. J., Seo, S. O., Lane, S., Park, Y. C., Jin, Y. S., and Seo, J. H. (2016) Enhanced production of 2,3-butanediol in pyruvate decarboxylase-deficient Saccharomyces cerevisiae through optimizing ratio of glucose/galactose. Biotechnology Journal, 11, 1424-1432
  • Park, J., Wang, Z., Lee, W. H., Jameel, H., Jin, Y. S., and Park, S. (2016) Effect of the two-stage autohydrolysis of hardwood on the enzymatic saccharification and subsequent fermentation with an efficient xylose-utilizing Saccharomyces cerevisiae. BioResources 11, 9584-9595
  • Xia, P. F., Zhang, G. C., Walker, B., Seo, S. O., Kwak, S., Liu, J., Kim, H., Ort, D., Wang, S. G., and Jin, Y. S. (2017) Recycling carbon dioxide during xylose fermentation by engineered Saccharomyces cerevisiae. ACS Synthetic Biology, in press
  • Turner, T. L., Kim, E., Hwang, C., Zhang, G., Liu, J., and Jin, Y. S. (2017) Conversion of lactose and whey into lactic acid by engineered yeast. Journal of Dairy Science, 100, 124-128
  • Lee, Y. J., Jin, Y. S., Cha, Y. L., and Seo, J. H. (2017) Bioethanol production from cellulosic hydrolysates by engineered industrial Saccharomyces cerevisiae. Bioresource Technology, in press
  • Seo, S. O., Wang, Y., Lu, T., Jin, Y. S., and Blaschek, H. P. (2017) Characterization of a Clostridium beijerinckii spo0A mutant and its application for butyl butyrate production. Biotechnology and Bioengineering, 114, 106-112
  • Zhang, G. C., Turner, T. L., Jin, Y. S. (2017) Enhanced xylose fermentation by engineered yeast expressing NADH oxidase through high cell density inoculums. Journal of Industiral Microbiology and Biotechnology, in press

Bioengineering

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