directory

Rohit Bhargava

Rohit Bhargava
Founder Professor in Bioengineering and Bliss Faculty Scholar
(217) 265-6596
4265 Beckman Institute

Research Topics

  • Bioimaging at Multi-Scale

Education

  • Ph.D. (Macromolecular Science and Engineering), Case Western Reserve University, Cleveland, Ohio, 2000.

Academic Positions

  • Co-Leader, HABITS--Health: Attitudes, Biology, Information Technology, Society Initiative, Beckman Institute, 2010-2014
  • Affiliate Faculty, Computational Science and Engineering Program, University of Illinois at Urbana-Champaign, Urbana, IL, 2006-present
  • Faculty, Micro and Nanotechnology Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL, 2008- present
  • Research Affiliate, Mills Breast Cancer Institute, Carle Foundation Hospital, 2010-present
  • Affiliate Faculty, Department of Mechanical Science & Engineering, Electrical & Computer Engineering, Chemical & Biomolecular Engineering,University of Illinois at Urbana-Champaign, Urbana, IL, 2011-present
  • Associate Director and member, University of Illinois Cancer Center, University of Illinois at Urbana-Champaign, Urbana, IL, 2011-2016
  • Full-time faculty, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, 2005-present
  • Assistant Professor, Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL, 2005-2011
  • Associate Professor, Department of Bioengineering,University of Illinois at Urbana-Champaign, Urbana, IL, 2011-2012
  • Bliss Faculty Scholar, University of Illinois at Urbana-Champaign, Urbana, IL., 2012-2016
  • Director, Cancer Center at Illinois, University of Illinois at Urbana-Champaign, 2016-present
  • Founder Professor in Engineering, College of Engineering, University of Illinois at Urbana-Champaign, Urbana, IL. 2016-present
  • Professor, University of Illinois at Urbana-Champaign, Urbana, IL. 2012-present

For more information

Research Topics

  • Bioimaging at Multi-Scale

Research Interests

  • Cancer nanotechnology
  • 3D printing
  • Cancer pathology
  • Fourier transform infrared spectroscopy
  • Chemical Imaging - infrared and Raman

Chapters in Books

  • R. Bhargava, I. W. Levin "Recent developments in Fourier transform infrared (FTIR) microspectroscopic methods for biomedical analyses: From single-point detection to two-dimensional imaging" Biomedical Photonics Handbook, T. Vo-Dinh, ed., CRC Press, Boca Raton, FL (2002).
  • R. Bhargava, I. W. Levin "Mid-infrared spectroscopic imaging with multichannel detectors" Spectrochemical Analyses Using Infrared Multichannel Detectors, R. Bhargava, I. W. Levin, eds., Blackwell Publishing (2005).
  • R. Bhargava, M. D. Schaeberle, I. W. Levin "Raman and mid-infrared microspectroscopic imaging" Vibrational Spectroscopy of Biological and Polymeric Materials, V. G. Gregariou, M. Braiman, eds., CRC Press, Boca Raton, FL (2005).
  • R. Bhargava, I. W. Levin, "Infrared spectroscopic imaging protocols for high-throughput histopathology" Vibrational Spectroscopy for Medical Diagnosis, M. Diem, P. R. Griffiths, J. Chalmers, eds., John Wiley and Sons, Chichester, UK (2008).
  • A. K. Kodali, R. Bhargava "Nanostructured probes to enhance optical and vibrational spectroscopic imaging for biomedical applications" The Oxford Handbook of Nanoscience and Technology: Vol. III: Applications, Y. Y. Fu, A. Narlikar, eds., Oxford University Press, Oxford, UK (2010).
  • R. K. Reddy, R. Bhargava “Chemometric methods for biomedical vibrational spectroscopy and imaging” Emerging Raman Applications and Techniques in Biomedical and Pharmaceutical Fields, M.D. Morris, P. Matousek, eds., Springer-Verlag, Berlin, Germany (2010).
  • F. N. Pounder, R. Bhargava “Toward automated breast histopathology using mid-IR spectroscopic imaging” Vibrational Spectroscopic Imaging for Biomedical Applications, G. Srinivasan, ed., McGraw-Hill, New York, NY (2010).
  • M. J. Walsh, R. Bhargava “Infrared spectroscopic imaging: An integrative approach to pathology” Nanobiophotonics, G. Popescu, ed., McGraw-Hill, New York, NY (2010).
  • K. Yeh, R. K. Reddy, R. Bhargava “Fourier transform infrared spectroscopic imaging” Emerging Imaging Technologies in Medicine, M. A. Anastasio, P. La Riviere, eds., Taylor Francis/CRC Press, Boca Raton, FL (2012).

Books Edited or Co-Edited (Original Editions)

  • R. Bhargava, I. W. Levin, eds. Spectrochemical Analyses Using Multichannel Infrared Detectors, Blackwell Publishing Ltd., Oxford, UK, 2005.

Selected Articles in Journals

  • M.K. Gelber, M.R. Kole, N. Kim, N. Aluru, R. Bhargava “Quantitative Chemical Imaging Within Non-Planar Microfluidics” Anal. Chem. In press (2017).
  • T.P. Wrobel, P. Mukherjee, R. Bhargava “Rapid visualization of macromolecular orientation by discrete mid-infrared spectroscopic imaging” Analyst 142, 75-79 (2017).
  • S. Berisha, T. van Dijk, R. Bhargava, P.S. Carney, D. Mayerich “BIM-Sim: Interactive Simulation of Broadband Imaging Using Mie Theory” Fron. Phys.: Opt. Phot. In press (2017).
  • T.Q. Doan, L.S. Leslie, S.Y. Kim, R. Bhargava, S.R. White, N. Sottos “Characterization of core-shell microstructure and self-healing performance of electrospun fiber coatings” Polymer 107, 263-272 (2016).
  • S. Tiwari, C. Hoke, V. Reddy, J. Raman, R. Bhargava “Translating infrared spectroscopic imaging for rapid analysis of biopsy samples using a discrete frequency approach” Anal. Chem. 88, 10183-10190 (2016).
  • F. Ostadhossein, S.K. Misra, P. Mukherjee, A. Ostadhossein, E. Daza, S. Tiwari, S. Mittal, M.C. Gryka, R. Bhargava, D. Pan “Breast Cancer Therapy: Defined host-guest chemistry on Nanocarbon for sustained inhibition of cancer” Small 12, 5782-5782 (2016).
  • B.M. DeVetter, S. Kenkel, S. Mittal, R. Bhargava, T. Wrobel “Characterization of structure of low-e substrates and consequences for IR transflection measurements” Vib. Spectrosc. In press (2016).
  • P. Mukherjee, S.J. Lim, T.P. Wrobel, R. Bhargava,* A.M. Smith* “Measuring and predicting the internal structure of semiconductor nanocrystals through Raman spectroscopy” J. Am. Chem. Soc. 138, 10887-10896 (2016) [*joint corresponding authors]
  • S.K. Misra, P. Mukherjee, H-H. Chang, S. Tiwari, M. Gryka, R. Bhargava, D. Pan “Multi-functionality Redefined with Colloidal Carotene Carbon Nanoparticles for Synchronized Chemical Imaging, Enriched Cellular Uptake and Therapy” Sci. Rep. 6, Article 29299 (2016).
  • T.P. Wrobel, M. Kole, R. Bhargava “Emerging trends and opportunities in discrete frequency infrared and Raman spectroscopic imaging” Spectroscopy 31, 28-45 (2016). - Invited
  • J. T. Kwak, S. M. Hewitt, A. Kajdacsy-Balla, S. Sinha, R. Bhargava “Automated prostate tissue referencing for cancer detection and diagnosis” BMC Bioinformatics 17, 227 (2016).
  • F.N. Keith, R.K. Reddy, R. Bhargava “Development of a practical spatial-spectral analysis protocol for breast histopathology using Fourier transform infrared spectroscopic imaging” Faraday Discuss. 187, 43-68 (2016). - Invited
  • S.E. Dubowsky, B. Deutsch, R. Bhargava, B. McCall “Infrared Emission Spectroscopy of Atmospheric-Pressure Ball Plasmoids” J. Mol. Spectrosc. 322, 1-8 (2016).
  • S.K. Misra, P. Mukherjee, A. Ohoka, A.S. Schwartz-Duval, S. Tiwari, R. Bhargava, D. Pan “Vibrational spectroscopy and imaging for concurrent cellular trafficking of co-localized Doxorubicin and deuterated phospholipid vesicles” Nanoscale 8, 2826-2831 (2016).
  • R. Bhargava, A. Madabhushi “Emerging themes in image informatics and molecular analysis for digital pathology” Annu. Rev. Biomed. Engr. 18, 387–412 (2016). - Invited
  • S. Tiwari, R. Bhargava “Extracting knowledge from chemical imaging data using computational algorithms for digital cancer diagnosis” Yale J. Biol. Med. 88, 131–143 (2015).
  • P. Mukherjee, S. K. Misra, M. Gryka, H. Chang, S. Tiwari, W. L. Wilson, J. Scott, R. Bhargava, D. Pan “Tunable luminescent carbon nanospheres with well-defined nanoscale chemistry for synchronized imaging and therapy” Small 36, 4691–4703 (2015).
  • L. S. Leslie, T. P. Wrobel, D. Mayerich, S. Bindra, R. Emmadi, R. Bhargava “High definition infrared spectroscopic imaging for lymph node histopathology” PLOS ONE 10, e0127238 (2015).
  • B. Deutsch, R. Reddy, D. Mayerich, R. Bhargava, P. S. Carney “Compositional prior information in computed infrared spectroscopic imaging” J. Opt. Soc. Am. A 32, 1126–1131 (2015).
  • J. Han, W. Qiu, S. Tiwari, R. Bhargava, W. Gao, B. Xing “Consumer-grade polyurethane foam functions as a large and selective absorption sink for bisphenol A in aqueous media” J. Mater. Chem. A 3, 8870–8881 (2015).
  • S. Tiwari, J. Reddy, R. Bhargava, J. Raman “Computational chemical imaging for cardiovascular pathology: Chemical microscopic imaging accurately determines cardiac transplant rejection” PLOS ONE 10, e1025183 (2015).
  • B. M. DeVetter, P. Mukherjee, C. J. Murphy, R. Bhargava “Measuring binding kinetics of aromatic thiolated molecules with nanoparticles via surface-enhanced Raman spectroscopy” Nanoscale 7, 8766–8775 (2015).
  • M. K. Gelber, R. Bhargava “Monolithic multilayer microfluidics via sacrificial molding of 3D-printed isomalt” Lab Chip 15, 1736–1741 (2015).
  • B. Chng, R. Bhargava, P. S. Carney “Enhancement and extinction effects in surface-enhanced stimulated Raman spectroscopy” Phys. Chem. Chem. Phys. 17, 21348-21355 (2015).
  • J. T. Kwak, A. Kajdacsy-Balla, V. Macias, M. Walsh, S. Sinha, R. Bhargava “Improving prediction of prostate cancer recurrence using chemical imaging” Sci. Rep. 5, 8758 (2015).
  • D. Mayerich, M. J. Walsh, A. Kadjacsy-Balla, P. S. Ray, S. M. Hewitt, R. Bhargava “Stain-less staining for computed histopathology” Technology 3, 27–31 (2015).
  • T. van Dijk, D. Mayerich, P.S. Carney, R. Bhargava "Understanding the optics-sample interaction in infrared spectroscopic imaging" Analyst 139, 4031-4036 (2015).
  • K. Yeh, S. Kenkel, J.-N. Liu, R. Bhargava “Fast infrared chemical imaging with a quantum cascade laser” Anal. Chem. 87, 485–493 (2015).
  • B. M. DeVetter, S. T. Sivapalan, D. D. Patel, M. V. Schulmerich, C. J. Murphy, R. Bhargava “Observation of molecular diffusion in polyelectrolyte-wrapped SERS nanoprobes” Langmuir 30, 8931–8937 (2014).
  • J.-N. Liu, M. V. Schulmerich, R. Bhargava, B. T. Cunningham “Sculpting narrowband Fano resonances inherent in the large-area mid-infrared photonic crystal microresonators for spectroscopic imaging” Opt. Express 22, 18142–18158 (2014).
  • A. Rosenberg, J. Surya, R. Liu, W. Streyer, S. Law, L. S. Leslie, R. Bhargava, D. Wasserman “Flat mid-infrared composite plasmonic materials using lateral doping-patterned semiconductors” J. Optics 16, 094012 (2014).
  • M.J. Baker, J. Trevisan, P. Bassan, R. Bhargava, H. J. Butler, K. M. Dorling, P. R. Fielden, S. W. Fogarty, N. J. Fullwood, K. A. Heys, C. Hughes, P. Lasch, P. L. Martin-Hirsch, B. Obinaju, G. D. Sockalingum, J. Sulé-Suso, R. J. Strong, M. J. Walsh, B. R. Wood, P. Gardner and F. L. Martin “Using Fourier transform IR spectroscopy to analyze biological materials” Nat. Protocols 9, 1771–1791 (2014) doi:10.1038/nprot.2014.110.
  • S. E. Holton, A. Bergamaschi, B. S. Katzenellenbogen, R. Bhargava “Integration of molecular profiling and chemical imaging to elucidate fibroblast-microenvironment impact on cancer cell phenotype and endocrine resistance in breast cancer” PLOS ONE 9, e96878 (2014).
  • D. Mayerich, T. van Dijk, M. Walsh, M. Schulmerich, P. S. Carney, R. Bhargava “On the importance of image formation optics in the design of infrared spectroscopic imaging systems” Analyst 139, 4031–4036 (2014).
  • B. M. DeVetter, R. Bhargava, C. J. Murphy “Computational study of the surface-enhanced Raman scattering from silica-coated silver nanowires” Photochem. Photobiol. 90, 415–418 (2014) doi:10.1111/php.12205.
  • B. Kwon, M. Seong, J.-N. Liu, M. R. Rosenberger, M. V. Schulmerich, R. Bhargava, B. T. Cunningham, W. P. King “Large infrared absorbance of bimaterial microcantilevers based on silicon high contrast grating” J. Appl. Phys. 114, 153511 (2013) doi:10.1063/1.4825313.
  • M. V. Schulmerich, M. K. Gelber, H. M. Azam, S. K. Harrison, J. McKinney, D. Thompson, B. Owen, L. S. Kull, R. Bhargava "Amino acid quantification in bulk soybeans by transmission Raman spectroscopy" Anal. Chem. 85, 11376–11381 (2013).
  • B. Kwon, J. Jiang, M. V. Schulmerich, Z. Xu, R. Bhargava, G. L. Liu, W. P. King “Bimaterial microcantilevers with black silicon nanocone arrays” Sens. Actuators, A 199, 143–148 (2013)
  • T. van Dijk, D. Mayerich, R. Bhargava, P. S. Carney “Rapid spectral-domain localization” Opt. Express 21, 12822–12830 (2013).
  • S. T. Sivapalan, B. M. DeVetter, T. K. Yang, M. V. Schulmerich, R. Bhargava, C. J. Murphy “Surface-enhanced Raman spectroscopy of polyelectrolyte-wrapped gold nanoparticles in colloidal suspension” J. Phys. Chem. C 117, 10677–10682 (2013).
  • D. Mayerich, M. Walsh, M. Schulmerich, R. Bhargava “Real-time interactive data mining for chemical imaging information: Application to automated histopathology” BMC Bioinformatics 14, 156 (2013) [Designated "Highly Accessed"].
  • T. van Dijk, D. Mayerich, P. S. Carney, R. Bhargava “Recovery of absorption spectra from Fourier transform infrared (FT-IR) microspectroscopic measurements of intact spheres” Appl. Spectrosc. 67, 546–552 (2013).
  • T. van Dijk, S. T. Sivapalan, B. M. DeVetter, T. K. Yang, M. V. Schulmerich, C. J. Murphy, R. Bhargava, P. S. Carney “Competition between extinction and enhancement in surface-enhanced Raman spectroscopy” J. Phys. Chem. Lett. 4, 1193–1196 (2013).
  • A. B. Shah, S. T. Sivapalan, B. M. DeVetter, T. K. Yang, J. Wen, R. Bhargava, C. J. Murphy, J.-M. Zuo “High-index facets in gold nanocrystals elucidated by coherent electron diffraction” Nano Lett. 13, 1840–1846 (2013).
  • Y. Liu, C. Zhang, D. Hu, M. S. Kuhlenschmidt, T. B. Kuhlenschmidt, S. E. Mylon, R. Kong, R. Bhargava, T. H. Nguyen “Role of collector alternating charged patches on transport of Cryptosporidium parvum oocyst in a patchwise charged heterogeneous micromodel" Environ. Sci. Technol. 47, 2670–2678 (2013) doi:10.1021/es304075j.
  • A. K. Kodali, M. Schulmerich, R. Palekar, R. Bhargava “Sculpting the analytical volume in and around nanoparticle sensors using a multilayer geometry” Anal. Chem. 85, 3842–3848 (2013).
  • S. T. Sivapalan, B. M. DeVetter, T. K. Yang, T. van Dijk, M. V. Schulmerich, P. S. Carney, R. Bhargava, C. J. Murphy “Off-resonance SERS from gold nanorod suspensions as a function of aspect ratio: Not what we thought” ACS Nano 7, 2099–2105 (2013).
  • A. Abouimrane, S. A. Odom, H. Tavassol, M. V. Schulmerich, H. Wu, R. Bhargava, A. A. Gewirth, J. S. Moore, K. Amine “3-Hexylthiophene as a stabilizing additive for high voltage cathodes in lithium-ion batteries” J. Electrochem. Soc. 160, A268–A271 (2013).
  • B. Kwon, M. V. Schulmerich, R. Bhargava, W. P. King “Infrared emission from heated microcantilevers” Nanosc. Microsc. Thermophys. Eng. 17, 141–153 (2013).
  • J. G. Moreno-Torres, X. Llorà, D. E. Goldberg, R. Bhargava “Repairing fractures between data using genetic programming-based feature extraction: A case study in cancer diagnosis” Info. Sci. 222, 805–823 (2013).
  • R. K. Reddy, M. J. Walsh, M. V. Schulmerich, P. S. Carney, R. Bhargava "High-definition infrared spectroscopic imaging" Appl. Spectrosc. 67, 93–105 (2013).
  • M. R. Kole, R. K. Reddy, M. V. Schulmerich, M. K. Gelber, R. Bhargava “Discrete frequency infrared microspectroscopy and imaging with a tunable quantum cascade laser” Anal. Chem. 84, 10366–10372 (2012) doi:10.1021/ac302513f.
  • R. Bhargava “Infrared spectroscopic imaging: The next generation” Appl. Spectrosc. 66, 1091–1120 (2012) [Invited Focal Point Article].
  • R. Ambekar, T.-Y. Lau, M. Walsh, R. Bhargava, K. C. Toussaint Jr “Quantifying collagen structure in breast biopsies using second-harmonic generation imaging” Biomed. Opt. Express 3, 2021–2035 (2012).
  • M. V. Schulmerich, M. J Walsh, M. K. Gelber, R. Kong, M. R. Kole, S. K. Harrison, J. McKinney, D. Thompson, L. S. Kull, R. Bhargava “Protein and oil composition predictions of single soybeans by transmission Raman spectroscopy” J. Agric. Food. Chem. 60, 8097–8102 (2012).
  • S. A. Odom, T. P. Tyler, M. M. Caruso, J. A. Ritchey, M. V. Schulmerich, S. J. Robinson, R. Bhargava, N. R. Sottos, S. R. White, M. C. Hersam, J. S. Moore “Autonomic restoration of electrical conductivity using polymer-stabilized carbon nanotube and graphene microcapsules” Appl. Phys. Lett. 101, 043106 (2012).
  • N. Lu, S. E. Mylon, R. Kong, R. Bhargava, J. L. Zilles, T. H. Nguyen “Interactions between dissolved natural organic matter and adsorbed DNA and their effect on natural transformation of Azotobacter vinelandii” Sci. Total Environ. 426, 430–435 (2012).
  • M. J. Walsh, R. K. Reddy, R. Bhargava “Label-free biomedical imaging with mid-infrared microspectroscopy” IEEE J. Sel. Top. Quant. Electron. 18,1502–1513 (2012) [Invited] doi:10.1109/JSTQE.2011.2182635.
  • M. J. Walsh, S. E. Holton, A. Kajdacsy-Balla, R. Bhargava “Attenuated total reflectance Fourier-transform infrared spectroscopic imaging for comprehensive breast tissue histopathology” Vib. Spectrosc. 60, 23–28 (2012) doi:10.1016/j.vibspec.2012.01.010.
  • B. Kwon, M. V. Schulmerich, L. J. Elgass, R. Kong, S. E. Holton, R. Bhargava, W. P. King “Infrared microspectroscopy combined with conventional atomic force microscopy” Ultramicroscopy 116, 56–61 (2012).
  • J. T. Kwak, R. K. Reddy, S. Sinha, R. Bhargava “Analysis of variance in spectroscopic imaging data from human tissues” Anal. Chem. 84, 1063–1069 (2012) doi:10.1021/ac2026496.
  • B. Kwon, M. Rosenberger, R. Bhargava, D. G. Cahill, W. P. King “Dynamic thermomechanical response of bimaterial microcantilevers to periodic heating by infrared radiation” Rev. Sci. Instrum. 83, 015003 (2012) doi:10.1063/1.3680107.
  • D. M. Mahr, R. Bhargava, M. F. Insana “Three-dimensional in silico breast phantoms for multimodal image simulations” IEEE Trans. Med. Imaging 31, 689–697 (2012) doi:10.1109/TMI.2011.2175401.
  • J.-N. Liu, M. V. Schulmerich, R. Bhargava, B. T. Cunningham “Optimally designed narrowband mid-infrared guided-mode resonance reflectance filters for mid-infrared spectroscopy” Opt. Express 19, 24182–24197 (2011) doi:10.1364/OE.19.024182.
  • D. Chanda, K. Shigeta, T. Truong, E. Lui, A. Mihi, M. Schulmerich, P. V. Braun, R. Bhargava, J. A. Rogers “Coupling of plasmonic and optical cavity modes in quasi-three-dimensional plasmonic crystals” Nat. Commun. 2, 479 (2011) doi:10.1038/ncomms1487.
  • A. K. Kodali, R. Bhargava “Effect of non-specificity in shape, size, and dielectric properties on electromagnetic extinction and optical field enhancement from spherical nanolayered metal-dielectric particles" Theor. Chem. Acc. 130, 991–1000 (2011) [Invited] doi:10.1007/s00214-011-1038-1.
  • S. E. Holton, M. J. Walsh, A. Kajdacsy-Balla, R. Bhargava “Label-free characterization of cancer-activated fibroblasts in cell culture and clinical tissues using infrared spectroscopic imaging” Biophys. J. 101, 1513–1521 (2011) doi:10.1016/j.bpj.2011.07.055.
  • J. Yao, A.-P. Le, M. V. Schulmerich, J. Maria, T.-W. Lee, S. K. Gray, R. Bhargava, J. A. Rogers, R. G. Nuzzo “Soft embossing of nanoscale optical and plasmonic structures in glass” ACS Nano 5, 5763–5774 (2011) doi:10.1021/nn201464t.
  • S. E. Holton, M. J. Walsh, R. Bhargava “Subcellular localization of early biochemical transformations in cancer-activated fibroblasts using infrared spectroscopic imaging” Analyst 136, 2953–2958 (2011) doi:10.1039/c1an15112f.
  • R. Kong, R. Bhargava “Characterization of porcine skin as a model for human transdermal diffusion” Analyst 136, 2359–2366 (2011) doi:10.1039/C1AN15111H.
  • M. J. Nasse, M. J. Walsh, E. C. Mattson, R. Reininger, A. Kajdacsy-Balla, V. Macias, R. Bhargava,* C. J. Hirschmugl* “High-resolution Fourier-transform infrared chemical imaging with multiple synchrotron beams” Nat. Methods 8, 413–416 (2011) doi:10.1038/NMETH.1585 [*Joint corresponding authors].
  • J. T. Kwak, S. M. Hewitt, S. Sinha, R. Bhargava “Multimodal microscopy for automated histologic analysis of prostate cancer” BMC Cancer 11, 62 (2011) [Designated “Highly Accessed”].
  • B. J. Davis, P. S. Carney, R. Bhargava “Theory of infrared microspectroscopy for intact fibers” Anal. Chem. 83, 525–532 (2011).
  • B. Kwon, C. Wang, K. Park, R. Bhargava, W. P. King “Themomechanical sensitivity of microcantilevers in the mid-infrared spectral region” Nano Micro Thermophys. Eng. 15, 16–27 (2011).
  • J. G. Moreno-Torres, X. Llorà, D. E. Goldberg, R. Bhargava “On the homogenization of data from two laboratories using genetic programming” Lec. Notes Comp. Sci. 6471, 185–197 (2010) doi:10.1007/978-3-642-17508-4_12.
  • A. K. Kodali, M. V. Schulmerich, R. Palekar, X. Llora, R. Bhargava “Optimized nanospherical layered alternating metal-dielectric probes for optical sensing” Opt. Express 18, 23302–23313 (2010).
  • R. K. Reddy, R. Bhargava “Accurate histopathology from low signal-to-noise ratio spectroscopic imaging data” Analyst 135, 2818–2825 (2010) doi:10.1039/C0AN00350F.
  • A. K. Kodali, X. Llora, R. Bhargava “Optimally designed nanolayered metal dielectric particles as probes for massively multiplexed and ultrasensitive molecular assays” Proc. Natl. Acad. Sci. U. S. A. 107, 13620–13625 (2010) doi:10.1073/pnas.1003926107.
  • A. K. Kodali, M. Schulmerich, J. Ip, G. Yen, B. T. Cunningham, R. Bhargava “Narrowband midinfrared reflectance filters using guided mode resonance” Anal. Chem. 82, 5697–5706 (2010) doi:10.1021/ac1007128.
  • M. V. Schulmerich, R. Reddy, A. K. Kodali, L. J. Elgass, R. Bhargava “Dark field Raman microscopy” Anal. Chem. 82, 6273–6280 (2010) doi:10.1021/ac1014194.
  • R. Kong, R. K. Reddy, R. Bhargava “Characterization of tumor progression in engineered tissue using infrared spectroscopic imaging” Analyst 135, 1569–1578 (2010) doi:10.1039/c0an00112k.
  • B. J. Davis, P. S. Carney, R. Bhargava “Theory of mid-infrared absorption microspectroscopy. II. Heterogeneous samples” Anal. Chem., 82, 3487–3499 (2010) doi:10.1021/ac902068e.
  • B. J. Davis, P. S. Carney, R. Bhargava “Theory of mid-infrared absorption microspectroscopy. I. Homogeneous samples” Anal. Chem. 82, 3474–3486 (2010) doi:10.1021/ac902067p.
  • R. Bhargava, R. S. Perlman, D. C. Fernandez, I. W. Levin, E. G. Bartick “Non-invasive detection of superimposed latent fingerprints and inter-ridge trace evidence by infrared spectroscopic imaging” Anal Bioanal. Chem. 394, 2069–2075 (2009).
  • X. Llorà, A. Priya, R. Bhargava “Observer-invariant histopathology using genetics-based machine learning” Nat. Computing 8, 101–120 (2009).
  • K. Park, J. Lee, R. Bhargava, W. P. King “Routine femtogram-level chemical analyses using vibrational spectroscopy and self-cleaning scanning probe microscopy tips” Anal. Chem. 80, 3221–3228 (2008).
  • R. Bhargava “Towards a practical Fourier transform infrared chemical imaging protocol for cancer histopathology” Anal. Bioanal. Chem. 389, 1155–1169 (2007).
  • G. Srinivasan, R. Bhargava “Fourier transform infrared spectroscopic imaging: The emerging evolution from a microscopy tool to a cancer imaging modality” Spectroscopy, 22, 30–43 (2007).
  • R. Bhargava, S. M. Hewitt, I. W. Levin “Reply to Unrealistic expectations for IR microspectroscopic imaging” Nature Biotechnol. 25, 31–33 (2007).
  • R. Bhargava, D. C. Fernandez, S. M. Hewitt, I. W. Levin “High throughput assessment of cells and tissues: Bayesian classification of spectral metrics from infrared vibrational spectroscopic imaging data” Biochim Biophys Acta. 1758, 830–845 (2006).
  • D. C. Fernandez,* R. Bhargava,* S. M. Hewitt, I. W. Levin “Infrared spectroscopic imaging For histopathologic recognition” Nature Biotechnol. 23, 469–474 (2005) [*equal first authors].
  • I. W. Levin, R. Bhargava “Fourier transform infrared vibrational spectroscopic imaging: Integrating microscopy and molecular recognition” Annu. Rev. Phys. Chem. 56, 429–474 (2005).
  • R. Bhargava, I. W. Levin “Gram-Schmidt orthogonalization for rapid reconstructions of Fourier transform infrared spectroscopic imaging data” Appl. Spectrosc. 58, 995–1000 (2004).
  • R. Bhargava, I. W. Levin “Enhanced time-resolved Fourier transform infrared spectroscopic imaging for reversible dynamics” J. Phys. Chem. A 108, 3896–3901 (2004).
  • R. Bhargava, I. W. Levin “Probing the structure and dynamics of macromolecular composites by infrared spectroscopy and imaging” Vib. Spectrosc. 34, 13–24 (2004) [Invited Special Issue: Prominent Young Vibrational Spectroscopists].
  • R. Bhargava, S.-Q. Wang, J. L. Koenig “FTIR microspectroscopy of polymeric systems” Adv. Polym. Sci. 163, 137–191 (2003).
  • R. Bhargava, I. W. Levin “Time-resolved Fourier transform infrared spectroscopic imaging” Appl. Spectrosc. 57, 357–366 (2003) [Accelerated Publication].
  • R. Bhargava, I. W. Levin “Noninvasive imaging of molecular dynamics in heterogeneous materials” Macromolecules 36, 92–96 (2003) [Featured in Anal. Chem. News Section, July 2003].
  • S. W. Huffman, R. Bhargava, I. W. Levin “Generalized implementation of rapid-scan Fourier transform infrared spectroscopic imaging” Appl. Spectrosc. 56, 965–969 (2002) [Accelerated Publication].
  • R. Bhargava, I. W. Levin “Effective time averaging of multiplexed measurements: A critical analysis” Anal. Chem. 74, 1429–1435 (2002).
  • I. W. Levin, R. Bhargava “Fourier transform infrared imaging: A new spectroscopic tool for microscopic analyses of biological tissue” Trends Appl. Spectrosc. 3, 57–71 (2001).
  • R. Bhargava, D. C. Fernandez, M. D. Schaeberle, I. W. Levin “Theory and application of gain ranging to Fourier transform infrared spectroscopic imaging” Appl. Spectrosc. 54, 1580–1589 (2001).
  • R. Bhargava, I. W. Levin “Fourier transform infrared imaging: Theory and practice” Anal. Chem. 73, 5157–5167 (2001).
  • T. Ribar, J. L. Koenig, R. Bhargava “FTIR imaging of polymer dissolution. 2. Solvent/nonsolvent mixtures” Macromolecules 34, 8340–8346 (2001).
  • R. Bhargava, M. D. Schaeberle, D. C. Fernandez, I. W. Levin “Novel route to faster Fourier transform infrared spectroscopic imaging” Appl. Spectrosc. 55, 1079–1084 (2001).
  • J. L. Koenig, S.-Q. Wang, R. Bhargava “FTIR images: A new technique produces images worth a thousand spectra” Anal. Chem. 73, 361A–369A (2001) [Cover Feature Article].
  • R. Bhargava, D. C. Fernandez, M. D. Schaeberle, I. W. Levin “Effect of focal plane array cold shield aperture size on Fourier transform infrared imaging microspectrometer performance” Appl. Spectrosc. 54, 1743–1750 (2000).
  • T. Ribar, R. Bhargava, J. L. Koenig “FT-IR imaging of polymer dissolution by solvent mixtures. 1. Solvents” Macromolecules 33, 8842–8849 (2000).
  • R. Bhargava, S.-Q. Wang, J. L. Koenig “Processing FTIR imaging data for morphology visualization” Appl. Spectrosc. 54, 1690–1706 (2000).
  • R. Bhargava, B. G. Wall, J. L. Koenig “Comparison of the FT-IR mapping and imaging techniques applied to polymeric systems” Appl. Spectrosc. 54, 470–479 (2000).
  • R. Bhargava, S.-Q. Wang, J. L. Koenig “Route to higher fidelity FT-IR imaging” Appl. Spectrosc. 54, 486–495 (2000).
  • R. Bhargava, S.-Q. Wang, J. L. Koenig “Studying polymer-dispersed liquid-crystal formation by FTIR spectroscopy. 2. Phase separation and ordering” Macromolecules 32, 8989–8995 (1999).
  • R. Bhargava, S.-Q. Wang, J. L. Koenig “Studying polymer-dispersed liquid-crystal formation by FTIR spectroscopy. 1. Monitoring curing reactions” Macromolecules 32, 8982–8988 (1999).
  • R. Bhargava, T. Ribar, J. L. Koenig “Towards faster FT-IR imaging by reducing noise” Appl. Spectrosc. 53, 1313–1322 (1999).
  • R. Bhargava, S.-Q. Wang, J.-L. Koenig “FTIR imaging studies of a new two-step process to produce polymer dispersed liquid crystals” Macromolecules 32, 2748–2760 (1999).
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  • R. Bhargava, S.-Q. Wang, J. L. Koenig “FT-IR imaging of the interface in multicomponent systems using optical effects induced by differences in refractive index” Appl. Spectrosc. 52, 323–328 (1998) [Accelerated Publication].

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