Home » Directory

Rohit Bhargava
Profile Photo
Professor
rxb [at] illinois [dot] edu
4265 Beckman Institute
MC 251
405 N. Mathews
Urbana,IL 61801
Degrees
  • Ph.D. (Macromolecular Science and Engineering), Case Western Reserve University, Cleveland, Ohio, 2000.
Academic Positions
  • Co-Leader, HABITS--Health: Attitudes, Biology, Information Technology, Society Initiative, Beckman Institute, 2010-present
  • Affiliate Faculty, Computational Science and Engineering Program, University of Illinois at Urbana-Champaign, Urbana, IL, 2006-present
  • Faculty, Micro and Nanotechnology Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL, 2008- present
  • Research Affiliate, Mills Breast Cancer Institute, Carle Foundation Hospital, 2010-present
  • Affiliate Faculty, Department of Mechanical Science & Engineering, Electrical & Computer Engineering, Chemical & Biomolecular Engineering,University of Illinois at Urbana-Champaign, Urbana, IL, 2011-present
  • Associate Director and member, University of Illinois Cancer Center, University of Illinois at Urbana-Champaign, Urbana, IL, 2011-present
  • Full-time faculty, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, 2005-present
  • Assistant Professor, Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL, 2005-2011
  • Associate Professor, Department of Bioengineering,University of Illinois at Urbana-Champaign, Urbana, IL, 2011-2012
  • Professor and Bliss Faculty Scholar, University of Illinois at Urbana-Champaign, Urbana, IL., 2012-present
More information
http://cisl.bioen.illinois.edu
http://cancer.illinois.edu
http://chemimage.illinois.edu
Book Chapters
  • R. Bhargava and I. W. Levin, "Recent Development in Fourier Transform Infrared (FTIR) Microspectroscopic Methods for Biomedical Analyses: From Single Point Detection to Two-Dimensional Imaging," Biomedical Photonics Handbook, CRC Press, Vo-Dinh Tran, ed., 2002.
  • R. Bhargava and I. W. Levin, "Mid-infrared Spectroscopic Imaging with Multichannel Detectors" in Spectrochemical Analyses using Multichannel Infrared Detectors, Blackwell Publishing, R. Bhargava and I. W. Levin, eds., 2005.
  • R. Bhargava, M. D. Schaeberle, and I. W. Levin, "Mid-infrared and Raman Spectroscopic Imaging" in Vibrational Spectroscopy of Biological and Polymeric Materials, Marcel Dekker, V. G. Gregariou and M. Braiman, eds., 2005.
  • R. Bhargava, I.W. Levin, "Prostate Cancer Diagnosis by FTIR Imaging," M. Diem, P.R. Griffiths and J. Chalmers, eds., 2009.
  • A.K. Kodali, R. Bhargava "Nanostructured Probes to Enhance Optical and Vibrational Spectroscopic Imaging for Biomedical Applications", Y.Y. Fu and A. Narlikar, eds. 2010.
  • R.K. Reddy, R. Bhargava “Chemometric methods for biomedical vibrational spectroscopy and imaging”, P. Matousek and M.D. Morris, eds. 2010.
  • F.N. Pounder, R. Bhargava “Breast cancer pathology by infrared spectroscopy”, G. Srinivasan, ed, McGraw-Hill (2010 – anticipated)
  • M.J. Walsh, R. Bhargava “Infrared spectroscopic imaging: an integrative approach to pathology” G. Popescu, ed. “Nanobiophotonics” McGraw-Hill (2010)
  • M.J. Walsh, R. Bhargava “Fourier transform infrared spectroscopic imaging” Emerging Imaging Technologies for Medicine, M. Anastasio and P. La Riviere, eds, Taylor Francis/CRC Press (in press)
Books Edited
  • R. Bhargava and I. W. Levin, eds., Spectrochemical Analyses Using Multichannel Infrared Detectors, Blackwell Publishing, UK, 2005
Journal Articles
  • • R. Bhargava, S.Q. Wang, J.L. Koenig “FT-IR imaging of the interface in multicomponent systems using optical effects induced by differences in refractive index” Appl. Spectrosc. 52, 323-328 (1998) [Accelerated Publication]
  • • U.S. Agarwal, R. Bhargava, R.A. Mashelkar “Brownian dynamics simulation of a polymer molecule in solution under elongational flow” J. Chem. Phys. 108, 1610-1616 (1998)
  • • R. Bhargava, S.Q. Wang, J.L. Koenig “FTIR imaging studies of a new two-step process to produce polymer dispersed liquid crystals” Macromolecules 32, 2748-2760 (1999)
  • • R. Bhargava, T. Ribar, J.L. Koenig “Towards faster FT-IR imaging by reducing noise” Appl. Spectrosc. 53, 1313-1322 (1999)
  • • R. Bhargava, S.Q. Wang, J.L. Koenig “Studying polymer-dispersed liquid-crystal formation by FTIR spectroscopy. 1. Monitoring curing reactions”, Macromolecules 32, 8982-8988 (1999)
  • • R. Bhargava, S.Q. Wang, J.L. Koenig “Studying polymer-dispersed liquid-crystal formation by FTIR spectroscopy. 2. Phase separation and ordering”, Macromolecules 32, 8989-8995 (1999)
  • • R. Bhargava, S.Q. Wang, J.L. Koenig “Route to higher fidelity FT-IR imaging” Appl. Spectrosc. 54, 486-495 (2000)
  • • R. Bhargava, B.G. Wall, J.L. Koenig “Comparison of the FT-IR mapping and imaging techniques applied to polymeric systems” Appl. Spectrosc. 54, 470-479 (2000)
  • • R. Bhargava, S.Q. Wang, J.L. Koenig “Processing FTIR Imaging Data for Morphology Visualization” Appl. Spectrosc. 54, 1690-1706 (2000)
  • • T. Ribar, R. Bhargava, J.L. Koenig “Examining Polymer Dissolution by FTIR Imaging: 1. Good Solvents” Macromolecules 33, 8842-8849 (2000)
  • • R. Bhargava, D.C. Fernandez, M.D. Schaeberle, I.W. Levin “Effect of Focal Plane Array Cold Shield Aperture Size on Fourier Transform Infrared Imaging Microspectrometer Performance”, Appl. Spectrosc. 54, 1743-1750 (2000)
  • • J.L. Koenig, S.Q. Wang, R. Bhargava “FTIR Images: A picture is worth a thousand spectra” Anal. Chem. 73, 351A-391A (2001) [Cover Feature Article]
  • • R. Bhargava, D.C. Fernandez, M.D. Schaeberle, I.W. Levin “Towards Faster FTIR Imaging” Appl. Spectrosc. 55, 1079-1084 (2001)
  • • T. Ribar, R. Bhargava, J.L. Koenig “Examining Polymer Dissolution by FTIR Imaging: 2. Good-Poor Solvent Mixtures” Macromolecules 34, 8340-8346 (2001)
  • • R. Bhargava, I.W. Levin “FTIR imaging: Theory and Practice” Anal. Chem. 73, 5157-5167 (2001)
  • • R. Bhargava, D.C. Fernandez, M.D. Schaeberle, I.W. Levin “Gain Ranging for FTIR Imaging” Appl. Spectrosc. 54, 1580-1589 (2001)
  • • R. Bhargava, I.W. Levin “Fourier Transform Infrared Spectroscopic Imaging of Biological Tissue” Trends Appl. Spectrosc. 3, 57-67 (2001)
  • • R. Bhargava, I.W. Levin “A Critical Analysis of Time Averaging and Multiplexing in Fourier Transform Infrared Spectroscopic Imaging” Anal. Chem. 74, 1429-1435 (2002)
  • • S.W. Huffman, R. Bhargava, I.W. Levin “A Generalized Implementation of Rapid-Scan Fourier Transform Infrared Spectroscopic Imaging” Appl. Spectrosc. 56, 965-969 (2002) [Accelerated Publication]
  • • R. Bhargava, I.W. Levin “Non-invasive Imaging of Molecular Dynamics in Heterogeneous Materials” Macromolecules 36, 92-96 (2003) [Featured in Anal. Chem. News Section, July 2003]
  • • R. Bhargava, I.W. Levin “Time Resolved Fourier Transform Infrared Spectroscopic Imaging” Appl. Spectrosc. 57, 357-366 (2003) [Accelerated Publication]
  • • R. Bhargava, S.Q. Wang, J.L. Koenig “FTIR Microspectroscopy of Polymeric Systems” Adv. Polym. Sci. 163, 137-191 (2003)
  • • R. Bhargava, I.W. Levin “Probing the Structure and Dynamics of Macromolecular Composites by Infrared Spectroscopy and Imaging” Vib. Spectrosc. 34, 13-24 (2004) [Invited Special Issue: Prominent Young Vibrational Spectroscopists]
  • • R. Bhargava, I.W. Levin “Enhanced Time-resolved Fourier Transform Infrared Spectroscopic Imaging for Reversible Dynamics” J. Phys. Chem. A 108, 3896-3901 (2004)
  • • R. Bhargava, I.W. Levin “Application of Gram-Schmidt Orthogonalization to Spectroscopic Imaging” Appl. Spectrosc. 58, 995-1000 (2004)
  • • I.W. Levin, R. Bhargava “Fourier Transform Infrared Vibrational Spectroscopic Imaging: Integration of Microscopy and Molecular Recognition” Annu. Rev. Phys. Chem., 56, 429-474 (2005)
  • • D.C. Fernandez,* R. Bhargava,* S.M. Hewitt, I.W. Levin “Infrared Spectroscopic Imaging For Histopathologic Recognition” Nature Biotechnol., 23, 469-474 (2005) [*equal first authors]
  • • R. Bhargava, D.C. Fernandez, S.M. Hewitt, I.W. Levin “High throughput assessment of cells and tissues: Bayesian classification of spectral metrics from infrared vibrational spectroscopic imaging data” Biochim Biophys Acta. 1758, 830-845 (2006)
  • • R. Bhargava, S.M. Hewitt, I.W. Levin “Re:Unrealistic Expectations for IR Microspectroscopic Imaging” Nature Biotechnol., 25, 31-33 (2007)
  • • G. Srinivasan, R. Bhargava “Fourier transform infrared spectroscopic imaging: the emerging evolution from a microscopy tool to a cancer imaging modality” Spectroscopy, 22, 40-51 (2007)
  • • R. Bhargava “Practical FTIR chemical imaging for cancer pathology” Anal. Bioanal. Chem., 389, 1155-1169 (2007)
  • • K. Park, J. Lee, R. Bhargava, W.P. King “Femtogram-Level Sampling for Spectroscopic Analysis Using Functional Self-Cleaning Scanning Probe Tips” Anal. Chem. 80, 3221 -3228 (2008)
  • • X. Llora, A.Priya, R. Bhargava “Observer-Invariant Histopathology using Genetics-Based Machine Learning” Nat. Computing, 8, 101-120 (2009)
  • • R. Bhargava, R.S. Perlman, D.C. Fernandez, I.W. Levin, E.G. Bartick “Non-invasive detection of superimposed latent fingerprints and inter-ridge trace evidence by infrared spectroscopic imaging” Anal Bioanal. Chem. 394, 2069–2075 (2009)
  • • B.J. Davis, P.S. Carney, R. Bhargava “Theory of mid-infrared absorption microspectroscopy. I. Homogeneous samples” Anal. Chem., 82, 3474–3486 (2010) DOI: 10.1021/ac902067p
  • • B.J. Davis, P.S. Carney, R. Bhargava “Theory of mid-infrared absorption microspectroscopy. II. Heterogeneous samples” Anal. Chem., 82, 3487–3499 (2010) DOI: 10.1021/ac902068e
  • • R. Kong, R.K. Reddy, R. Bhargava “Characterization of Tumor Progression in Engineered Tissue using Infrared Spectroscopic Imaging” Analyst 135, 1569-1578 (2010) DOI: 10.1039/c0an00112k
  • • M.V. Schulmerich, A.K. Kodali, R.K. Reddy, L.J. Elgass, R. Bhargava “Dark field Raman Microscopy” Anal. Chem., 82, 6273–6280 (2010) DOI: 10.1021/ac1014194
  • • A.K. Kodali, M.V. Schulmerich, J. Ip, G. Yen, B.T. Cunningham, R. Bhargava “Narrowband Mid-infrared reflectance filters using guided mode resonance” Anal. Chem., 82, 5697–5706 (2010) DOI: 10.1021/ac1007128
  • • A.K. Kodali, X. Llora, R. Bhargava “Optimally tailored Raman spectroscopic probes for ultrasensitive and highly multiplexed assays” Proc. Natl. Acad. Sci., 107, 13620-13625 (2010) DOI: 10.1073/pnas.1003926107
  • • R.K. Reddy, R. Bhargava “Automated noise reduction for accurate classification of tissue from low signal-to-noise ratio imaging data” Analyst, 135, 2818-2825 (2010) DOI: 10.1039/C0AN00350F
  • • A.K. Kodali, M.V. Schulmerich, R. Palekar, X. Llora, R. Bhargava “Optimized Nanospherical Layered Alternating Metal-dielectric Probes for Optical Sensing” Opt. Exp., 18, 23302-23313 (2010)
  • • J. G. Moreno-Torres, X. Llora, D.E. Goldberg, R. Bhargava “On the homogenization of data from two laboratories using genetic programming” Lec. Notes Comp. Sci., 6471/2010, 185-197 (2010), DOI: 10.1007/978-3-642-17508-4_12.
  • • B. Kwon, C. Wang, K. Park, R. Bhargava, W.P. King “Themomechanical Sensitivity of Microcantilevers in the Mid-infrared Spectral Region”, Nano Micro Thermophys Eng, 15, 16-28 (2011)
  • • B.J. Davis, P.S. Carney, R. Bhargava “Infrared Microspectroscopy of Intact Fibers” Anal. Chem. 83, 525–532. (2011)
  • • J.T. Kwak, S.M. Hewitt, S. Sinha, R. Bhargava “Multimodal microscopy for automated histologic analysis of prostate cancer” BMC Cancer 11, 62- (2011) [Designated “Highly Accessed”]
  • • J. G. Moreno-Torres, X. Llora, D.E. Goldberg, R. Bhargava “Repairing Fractures between Data using Genetic Programming-based Feature Extraction: A Case Study in Cancer Diagnosis” Information Sciences, In press (2011).
  • • M.J. Nasse, M.J. Walsh, E.C. Mattson, R. Reininger, A. Kajdacsy-Balla,V. Macias, R. Bhargava,* C.J. Hirschmugl* “High-resolution Fourier transform infrared chemical imaging with multiple synchrotron beams” Nat. Methods, 8, 413-416 (2011) DOI:10.1038/NMETH.1585 [*Joint corresponding authors]
  • • R. Kong, R. Bhargava “Characterization of Porcine Skin as a Model for Human Transdermal Diffusion” Analyst 136, 2359 - 2366 (2011) DOI: 10.1039/C1AN15111H
  • • S.E. Holton, M.J. Walsh, R. Bhargava “Localizing subcellular biochemical transformations in cancer-activated fibroblasts using high-resolution infrared spectroscopic imaging” Analyst 136, 2953-2958 (2011) DOI: 10.1039/c1an15112f
  • • J. Yao, A. Le, M.V. Schulmerich, J. Maria, T. Lee, S.K. Gray, R. Bhargava, J.A. Rogers, R.G. Nuzzo “Soft Embossing of Nanoscale Optical and Plasmonic Structures in Glass” ACS Nano, 5, 5763–5774 (2011) - DOI 10.1021/nn201464t.
  • • S. E. Holton, M.J. Walsh, A. Kajdacsy-Balla, R. Bhargava “Label-free characterization of cancer-activated fibroblasts in cell culture and clinical tissues using infrared spectroscopic imaging” Biophys. J. 101, 1513-1521 (2011) – DOI: 10.1016/j.bpj.2011.07.055
  • • A.K. Kodali, R. Bhargava “Effect of non-specificity in shape, size, and dielectric properties on electromagnetic extinction and optical field enhancement from spherical nanolayered metal-dielectric particles" Theor Chem Acc 130, 991-1000 (2011) [Invited] - DOI: 10.1007/s00214-011-1038-1
  • • D. Chanda, K. Shigeta, T. Truong, E. Lui, A. Mihi, M.V. Schulmerich, P.V. Braun, R. Bhargava, J.A. Rogers “Cavity-coupled quasi-three dimensional plasmonic crystals” Nat. Commun. 2, 479 (2011) DOI: 10.1038/ncomms1487
  • • J. Liu, M.V. Schulmerich, R. Bhargava, B.T. Cunningham “Optimally designed narrowband mid-infrared guided-mode resonance reflectance filters for mid-infrared optical spectroscopy” Opt. Exp. 19, 24182-24197 (2011). DOI: 10.1364/OE.19.024182
  • • D.M. Mahr, R. Bhargava, M.F. Insana “Multimodal image simulations using in-silico breast phantoms” IEEE Trans. Med. Imaging 31, 689 - 697 (2012). DOI: 10.1109/TMI.2011.2175401
  • B. Kwon, M. Rosenberger, R. Bhargava, D.G. Cahill, W.P. King “Dynamic Thermomechanical Response of Bimaterial Microcantilevers to Periodic Heating by Infrared Radiation” Rev. Sci. Instr. 83, 015003 (2012) DOI: 10.1063/1.3680107
  • J.T. Kwak, R.K. Reddy, S. Sinha, R. Bhargava “An analysis of the sources of variance in Fourier transform infrared spectroscopic imaging of tissues” Anal. Chem. 84, 1063-1069 (2012) DOI: 10.1021/ac2026496
  • B. Kwon, M.V. Schulmerich, S. Holton, R. Bhargava, W.P. King “Infrared microspectroscopy combined with conventional atomic force microscopy” Ultramicroscopy 116, 56-61. (2012)
  • M.J Walsh, S.E. Holton, A. Kajdacsy-Balla, R. Bhargava “Attenuated Total Reflectance Fourier Transform Infrared Spectroscopic Imaging for Comprehensive Breast Tissue Histopathology” Vib. Spectrosc. 60, 23-28 (2012) DOI: 10.1016/j.vibspec.2012.01.010
  • M.J. Walsh, R.K. Reddy, R. Bhargava “Label-free Biomedical Imaging with Mid-Infrared Microspectroscopy” IEEE J Sel Top Quant 18,1502 - 1513 (2012) [invited] DOI: 10.1109/JSTQE.2011.2182635
  • N. Lv, S.E. Mylon, R. Kong, R. Bhargava, J.L. Zilles, T.H. Nguyen “Interactions between dissolved natural organic matter and adsorbed DNA and their effect on natural transformation of Azotobacter vinelandii” Sci. Total Environ.. 426, 430-435 (2012)
  • S.A. Odom, T.P. Tyler, M.M. Caruso, J. Ritchey, M.V. Schulmerich, S.J. Robinson, R. Bhargava, N.R. Sottos, S.R. White, M.C. Hersam, J.S. Moore “Autonomic Restoration of Electrical Conductivity Using Polymer-Stabilized Carbon Nanotube and Graphene Microcapsules” Appl. Phys. Lett. 101, 043106 (2012)
  • R.K. Reddy, M.J. Walsh, M.V. Schulmerich, P.S. Carney, R. Bhargava “High-definition infrared spectroscopic imaging” Appl. Spectrosc. In press (2012)
  • • M.V. Schulmerich, M.J Walsh, M. Gelber, R. Kong, M. Kole, S. Harrison, J. McKinney, D. Thompson, L. Kull, R. Bhargava “Compositional analysis of soybean seed by Transmission Raman spectroscopy” J. Agric. Food. Chem. (2012)
  • R. Ambekar, T. Lau, M.J. Walsh, R. Bhargava, K. Toussaint “Quantifying collagen transformations in breast biopsies using second-harmonic generation imaging” Biomed. Opt. Exp. 3, 2021-2035 (2012)
  • R. Bhargava “Infrared Spectroscopic Imaging: The next generation” Appl. Spectrosc. In press (2012) [Invited Focal Point Article]
  • M. Kole, M.V. Schulmerich, M. Gelber, R. Bhargava “Discrete frequency infrared microspectroscopy and imaging with a tunable quantum cascade laser” Anal. Chem. In press (2012) DOI: dx.doi.org/10.1021/ac302513f
Research Service Honors
  • William F. Meggers Award, Society for Applied Spectroscopy
  • National Science Talent Search Scholar, NCERT, India
  • The Undergraduate Research Award, IIT-D
  • The Roll of Honour for Outstanding Cumulative Contribution as an Undergraduate
  • Samuel H. Maron Award, Case Western Reserve University
  • Sigma Pi Epsilon Honor Society, Society of Plastic Engineers
  • Case Alumni Award for Best Graduate Spectroscopist
  • William F. Kirkbright Bursary Award, Association of British Spectroscopists
  • William F. Meggers Award, Society for Applied Spectroscopy
  • Best Manuscript, Prominent Young Vibrational Spectroscopists' Issue of Vibrational Spectroscopy
  • Faculty Fellow, National Center for Supercomputing Applications
  • Bronze Medal, Human-Competitive Competition, GECCO07
  • DoD Young Investigator, Prostate Cancer Research program
  • Fellow, Center for Advanced Study
  • Xerox Award for Faculty Research
  • Campus award for outstanding promotion and tenure dossier
  • FACSS Innovation Award
Public Service Honors
  • Ramachandra Rao Dasari Lecture, Indian Institute of Technology, Kanpur
  • Society for Applied Spectroscopy National Tour Speaker